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Impact of aging on CD146+ mesenchymal stromal cells-mediated regulation of bone marrow CD34+ hematopoietic stem/progenitor cell mobilization

BackgroundThe study of age-associated changes in the bone marrow (BM), a key organ for hematopoiesis and immune regulation, is crucial to understanding inflammatory processes linked to cardiovascular diseases. Notably, aging is associated with impaired mobilization of BM-derived cardioprotective CD3...

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Furkejuvvon:
Váldodahkkit: Marzia Campanile, Miruna Larisa Naie, Milena Bertolotti, Ivan Muradore, Chiara Riccardi, Andrea Rampin, Giuseppe Noto, Paolo Angelo Laviano, Viola Melone, Domenico Palumbo, Roberta Tarallo, Alessandro Fantin, Elena Butoi, Gaia Spinetti
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2026-05-01
Ráidu:Frontiers in Bioengineering and Biotechnology
Fáttát:
aging
bone marrow
hematopoietic stem/progenitor cells
In vitro models
migration
stromal cells
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fbioe.2026.1802093/full
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