Impact of aging on CD146+ mesenchymal stromal cells-mediated regulation of bone marrow CD34+ hematopoietic stem/progenitor cell mobilization

BackgroundThe study of age-associated changes in the bone marrow (BM), a key organ for hematopoiesis and immune regulation, is crucial to understanding inflammatory processes linked to cardiovascular diseases. Notably, aging is associated with impaired mobilization of BM-derived cardioprotective CD3...

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Principais autores:	Marzia Campanile, Miruna Larisa Naie, Milena Bertolotti, Ivan Muradore, Chiara Riccardi, Andrea Rampin, Giuseppe Noto, Paolo Angelo Laviano, Viola Melone, Domenico Palumbo, Roberta Tarallo, Alessandro Fantin, Elena Butoi, Gaia Spinetti
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-05-01
Series:	Frontiers in Bioengineering and Biotechnology
Assuntos:	aging bone marrow hematopoietic stem/progenitor cells In vitro models migration stromal cells
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1802093/full
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