Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases

Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery and subsequently cleaved to yield the mature protein. MTSs do not have conserved amino acid compositions, but share common p...

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Principais autores:	Ashley L. Reed, Wayne Mitchell, Andrei T. Alexandrescu, Nathan N. Alder
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2023-11-01
סדרה:	Frontiers in Physiology
נושאים:	mitochondria amyloids neurodegeneration protein import cryptic targeting targeting signals
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1263420/full
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