Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases

Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery and subsequently cleaved to yield the mature protein. MTSs do not have conserved amino acid compositions, but share common p...

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Autori principali:	Ashley L. Reed, Wayne Mitchell, Andrei T. Alexandrescu, Nathan N. Alder
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-11-01
Serie:	Frontiers in Physiology
Soggetti:	mitochondria amyloids neurodegeneration protein import cryptic targeting targeting signals
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1263420/full
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