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Does Enhanced Structural Maturity of hiPSC-Cardiomyocytes Better for the Detection of Drug-Induced Cardiotoxicity?

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are currently used following the Comprehensive in vitro Proarrhythmic Assay (CiPA) initiative and subsequent recommendations in the International Council for Harmonization (ICH) guidelines S7B and E14 Q&A, to detect drug-induced...

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Principais autores: Dieter Van de Sande, Mohammadreza Ghasemi, Taylor Watters, Francis Burton, Ly Pham, Cristina Altrocchi, David J. Gallacher, Huarong Lu, Godfrey Smith
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-04-01
Serier:Biomolecules
Fag:
cell biology
cardio safety
hiPSC-CM
immature
CiPA
cardiac arrhythmia
Online adgang:https://www.mdpi.com/2218-273X/13/4/676
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