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Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits

Abstract Background Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effects of dexmedetomidine on the toll-like receptor 4 (TLR4)-mediated nucl...

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Principais autores: Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters, Hao Weng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-07-01
Serier:Journal of Translational Medicine
Fag:
Dexmedetomidine
Spinal cord ischemia–reperfusion injury
Neuroprotection
Apoptosis
Inflammatory responses
Online adgang:http://link.springer.com/article/10.1186/s12967-018-1583-7
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