Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains

Abstract In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation of pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well as after cerebral surgeries. Experimentally, intracerebral inoculation of brain homogen...

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Main Authors:	Anne-Sophie Hérard, Fanny Petit, Charlotte Gary, Martine Guillermier, Susana Boluda, Clément M. Garin, The Brainbank Neuro-CEB Neuropathology Network, Suzanne Lam, Marc Dhenain
Format:	Artigo
Language:	Inglês
Published:	BMC 2020-11-01
Series:	Acta Neuropathologica Communications
Subjects:	β-amyloid pathology Alzheimer’s disease Aβ transmission
Online Access:	https://doi.org/10.1186/s40478-020-01081-7
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