Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop

In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans peptide bonds in the N-terminal loop (loop-I). The equilibrium is shifted to the cis form in toxins with a pair of adjacent Pro residues in this...

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Bibliographic Details

Main Authors:	Peter V. Dubovskii, Anastasia A. Ignatova, Anna S. Alekseeva, Vladislav G. Starkov, Ivan A. Boldyrev, Alexey V. Feofanov, Yuri N. Utkin
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2022-12-01
Series:	Toxins
Subjects:	cobra cytotoxin antibacterial activity cytotoxic activity biological membrane spatial structure phospholipid liposomes
Online Access:	https://www.mdpi.com/2072-6651/15/1/6
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