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Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop

In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans peptide bonds in the N-terminal loop (loop-I). The equilibrium is shifted to the cis form in toxins with a pair of adjacent Pro residues in this...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Peter V. Dubovskii, Anastasia A. Ignatova, Anna S. Alekseeva, Vladislav G. Starkov, Ivan A. Boldyrev, Alexey V. Feofanov, Yuri N. Utkin
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-12-01
Schriftenreihe:Toxins
Schlagworte:
cobra cytotoxin
antibacterial activity
cytotoxic activity
biological membrane
spatial structure
phospholipid liposomes
Online-Zugang:https://www.mdpi.com/2072-6651/15/1/6
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