Molecular mechanisms and computational insights into human SGLTs: advancing toward selective SGLT1 inhibition

The sodium and glucose transporters (SGLTs) are integral membrane proteins crucial for glucose homeostasis, with SGLT1 and SGLT2 being widely studied as primary therapeutic targets. Despite SGLT2 inhibitors having been well clinically established, selective SGLT1 inhibition remains an unmet goal, al...

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Bibliografski detalji

Glavni autori:	Nadhiri Kaijage, Sebastian Kraszewski
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2025-10-01
Serija:	Frontiers in Molecular Biosciences
Teme:	sodium-glucose cotransporter 1 (SGLT1) sodium-glucose cotransporter 2 (SGLT2) selective SGLT1 inhibition glucose transport mechanisms cryo-electron microscopy (cryo-EM) molecular dynamics simulations
Online pristup:	https://www.frontiersin.org/articles/10.3389/fmolb.2025.1668400/full
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