Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series

Metastatic soft tissue sarcomas (STSs) are a heterogeneous group of rare mesenchymal tumors whose treatment options are limited. Our group has been interested in utilizing the synthetic toll-like receptor 4 (TLR4) agonist, glycopyranosyl lipid A in stable-emulsion formulation (GLA-SE), in patients w...

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المؤلفون الرئيسيون:	Jessica S. Zhang, Juliana C. K. Ng, Pedro Hermida de Viveiros, Rusul Al-Marayaty, Nourhane Al Akoum, Himaly Shinglot, Weiqing Jing, Valeria Vizcaino, Borislav A. Alexiev, Lee D. Cranmer, Elizabeth T. Loggers, Hannah Abrams, Michael J. Wagner, Venu G. Pillarisetty, Edward Y. Kim, Robert H. Pierce, Peter Berglund, Robin L. Jones, Hailing Lu, Jan ter Meulen, Seth M. Pollack, Yongwoo David Seo
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2026-05-01
سلاسل:	Frontiers in Oncology
الموضوعات:	Cancer vaccination intratumoral injection therapy metastatic leiomyosarcoma NY-ESO-1 T cell clonal expansion TLR4 agonist
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1829331/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!