Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series

Metastatic soft tissue sarcomas (STSs) are a heterogeneous group of rare mesenchymal tumors whose treatment options are limited. Our group has been interested in utilizing the synthetic toll-like receptor 4 (TLR4) agonist, glycopyranosyl lipid A in stable-emulsion formulation (GLA-SE), in patients w...

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Bibliografske podrobnosti

Principais autores:	Jessica S. Zhang, Juliana C. K. Ng, Pedro Hermida de Viveiros, Rusul Al-Marayaty, Nourhane Al Akoum, Himaly Shinglot, Weiqing Jing, Valeria Vizcaino, Borislav A. Alexiev, Lee D. Cranmer, Elizabeth T. Loggers, Hannah Abrams, Michael J. Wagner, Venu G. Pillarisetty, Edward Y. Kim, Robert H. Pierce, Peter Berglund, Robin L. Jones, Hailing Lu, Jan ter Meulen, Seth M. Pollack, Yongwoo David Seo
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-05-01
Serija:	Frontiers in Oncology
Teme:	Cancer vaccination intratumoral injection therapy metastatic leiomyosarcoma NY-ESO-1 T cell clonal expansion TLR4 agonist
Online dostop:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1829331/full
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