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Biomimetic siRNA-METTL3 loading nanosystem alleviates myocardial hypertrophy by regulating the FASN and SCD1 m6A modification

RNA m6A modification plays a vital role in regulating cardiac function; however, its comprehensive mechanisms require further exploration. We observed that the expression of METTL3, a m6A methyltransferase, is significantly increased in hypertrophic hearts as well as during phenylephrine (PE)-induce...

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Principais autores: Peng Teng, Xiaoyi Dai, Yuefeng Wu, Yingying Wang, Zhen Jia, Chenqiu Wang, Shixing Wang, Runhua Li, Qi Zheng, Yiming Ni, Wei Jiang, Liguo Jian, Datun Qi, Dongdong Jian, Liang Ma
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-08-01
coleção:Materials & Design
Assuntos:
Cardiac hypertrophy
METTL3
Platelet liposome fusion membrane
RNA modification
FASN
SCD1
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0264127525007087
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