Biomimetic siRNA-METTL3 loading nanosystem alleviates myocardial hypertrophy by regulating the FASN and SCD1 m6A modification

RNA m6A modification plays a vital role in regulating cardiac function; however, its comprehensive mechanisms require further exploration. We observed that the expression of METTL3, a m6A methyltransferase, is significantly increased in hypertrophic hearts as well as during phenylephrine (PE)-induce...

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Autores principales:	Peng Teng, Xiaoyi Dai, Yuefeng Wu, Yingying Wang, Zhen Jia, Chenqiu Wang, Shixing Wang, Runhua Li, Qi Zheng, Yiming Ni, Wei Jiang, Liguo Jian, Datun Qi, Dongdong Jian, Liang Ma
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-08-01
Colección:	Materials & Design
Materias:	Cardiac hypertrophy METTL3 Platelet liposome fusion membrane RNA modification FASN SCD1
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0264127525007087
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