Buprenorphine Substitution as a Tapering Strategy for Opioid Discontinuation in Patients with Chronic Pain: A Nonrandomized and Proof of Concept Study

Abstract Introduction Long-term use (≥ 3 months) of opioids for chronic noncancer pain (CNCP) shows limited benefit and often leads to dependence, especially when tapered too quickly. Standard opioid discontinuation typically involves gradual dose reduction, yet many patients fail to complete it. Me...

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Detalhes bibliográficos

Principais autores:	Célian Bertin, Nicolas Kerckhove, Florent Ferrer, Bruno Pereira, Christian Duale, Damien Richard, Nicolas Authier, Noémie Delage
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Adis, Springer Healthcare 2025-10-01
coleção:	Pain and Therapy
Assuntos:	Buprenorphine Non-cancer chronic pain Opioid tapering Opioid use disorder Proof-of-concept Pain clinic
Acesso em linha:	https://doi.org/10.1007/s40122-025-00781-z
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