Foot-and-mouth disease virus antigenic landscape and reduced immunogenicity elucidated in atomic detail

Abstract Unlike most other picornaviruses, foot-and-mouth disease (FMD) intact virions (146S) dissociate easily into small pentameric subunits (12S). This causes a dramatically decreased immunogenicity by a mechanism that remains elusive. Here, we present the high-resolution structures of 12S (3.2 Å...

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Autors principals:	Haozhou Li, Pan Liu, Hu Dong, Aldo Dekker, Michiel M. Harmsen, Huichen Guo, Xiangxi Wang, Shiqi Sun
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-10-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-53027-5
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