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Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

When a new activity evolves by changes in a pre-existing enzyme this is likely to reduce the original activity, generating a functional trade-off. The properties of this trade-off will affect the continued evolution of both functions. If the trade-off is strong, gene duplication and subsequent diver...

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Váldodahkkit: Erik Lundin, Joakim Näsvall, Dan I. Andersson
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2020-10-01
Ráidu:Frontiers in Microbiology
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Liŋkkat:https://www.frontiersin.org/article/10.3389/fmicb.2020.588235/full
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