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Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes

The contractile activity of cardiomyocytes (CMs) critical to heart function emerges from the collective shortening of sarcomeres. However, how these sarcomeric forces are transmitted within CMs during this process remains poorly understood. Traction force microscopy has been used to measure overall...

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Principais autores: Palash K. Dutta, Joshua M. Toth, Subramanian Sundaram, Xingyu Chen, Anant Chopra, Jourdan K. Ewoldt, Paige Cloonan, Xining Gao, Andrew S. LaCroix, Brenton D. Hoffman, Vivek B. Shenoy, Christine E. Seidman, Jonathan G. Seidman, Christopher S. Chen, Jeroen Eyckmans
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC 2026-02-01
coleção:APL Bioengineering
Acesso em linha:https://pubs.aip.org/aip/apb/article-pdf/doi/10.1063/5.0304143/20900627/016109_1_5.0304143.pdf
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