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Caloric Restriction Mimetic 2-Deoxyglucose Reduces Inflammatory Signaling in Human Astrocytes: Implications for Therapeutic Strategies Targeting Neurodegenerative Diseases

Therapeutic interventions are greatly needed for age-related neurodegenerative diseases. Astrocytes regulate many aspects of neuronal function including bioenergetics and synaptic transmission. Reactive astrocytes are implicated in neurodegenerative diseases due to their pro-inflammatory phenotype c...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Kaylie-Anna Juliette Vallee, Jerel Adam Fields
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-02-01
Schriftenreihe:Brain Sciences
Schlagworte:
neurodegenerative disease
caloric restriction
glycolysis
astrogliosis
inflammation
immunometabolism
Online-Zugang:https://www.mdpi.com/2076-3425/12/3/308
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