Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors

Novel 2- or 4-phosphonated 13α-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13α-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh3)4 as catalyst under microwave irradiation. The infl...

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Detalhes bibliográficos

Principais autores:	Rebeka Jójárt, Szabolcs Pécsy, György Keglevich, Mihály Szécsi, Réka Rigó, Csilla Özvegy-Laczka, Gábor Kecskeméti, Erzsébet Mernyák
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Beilstein-Institut 2018-11-01
coleção:	Beilstein Journal of Organic Chemistry
Assuntos:	catalysis enzyme 13α-estrone Hirao reaction 17β-HSD1 inhibition OATP2B1 STS
Acesso em linha:	https://doi.org/10.3762/bjoc.14.262
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