A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861

Abstract Background Treatment with tumor-targeted toxins attempts to overcome the disadvantages of conventional cancer therapies by directing a drug’s cytotoxic effect specifically towards cancer cells. However, success with targeted toxins has been hampered as the constructs commonly remain bound t...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Finn J. Schulze, Mazdak Asadian-Birjand, Michael Pradela, Nicole Niesler, Gregor Nagel, Hendrik Fuchs
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-04-01
Schriftenreihe:	BMC Biotechnology
Schlagworte:	Molecular adapter Glycosylated triterpenoid Endosomal escape Drug delivery Cancer treatment Epidermal growth factor
Online-Zugang:	https://doi.org/10.1186/s12896-024-00854-5
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