Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69.

Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy against adult filarial worms. To expedite the elimination of both...

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Principais autores:	Mark McHugh, Charity N Njeshi, Nathaniel Smith, Sudhanva S Kashyap, Real Datta, Han Sun, Alan P Robertson, Richard J Martin
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2025-09-01
叢編:	PLoS Pathogens
在線閱讀:	https://doi.org/10.1371/journal.ppat.1012946
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