Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69.

Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy against adult filarial worms. To expedite the elimination of both...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Mark McHugh, Charity N Njeshi, Nathaniel Smith, Sudhanva S Kashyap, Real Datta, Han Sun, Alan P Robertson, Richard J Martin
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Public Library of Science (PLoS) 2025-09-01
Цуврал:	PLoS Pathogens
Онлайн хандалт:	https://doi.org/10.1371/journal.ppat.1012946
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!