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DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs

Rapid-acting antidepressants show that mood can lift within hours when glutamatergic circuits shift from an “NMDA-dominant” to an “AMPA-dominant” state. Intravenous ketamine achieves this flip but is hampered by dissociation and logistics, while dextromethorphan + bupropion (Auvelity®) primarily sup...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Kaituhi matua: Ngo Cheung
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2026-03-01
Rangatū:Frontiers in Psychiatry
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1751605/full
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