DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs
Rapid-acting antidepressants show that mood can lift within hours when glutamatergic circuits shift from an “NMDA-dominant” to an “AMPA-dominant” state. Intravenous ketamine achieves this flip but is hampered by dissociation and logistics, while dextromethorphan + bupropion (Auvelity®) primarily sup...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers Media S.A.
2026-03-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1751605/full |
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