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TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients

IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase of post-translational modifications in TDP-43, such...

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Principais autores: Loreto Martinez-Gonzalez, Eva P. Cuevas, Carlota Tosat-Bitrián, Vanesa Nozal, Carmen Gil, Valle Palomo, Ángeles Martín-Requero, Ana Martinez
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-08-01
Serier:Frontiers in Molecular Neuroscience
Fag:
TDP-43 pathology
Alzheimer’s disease
CK1 inhibitor
TTBK1 inhibitor
drug discovery
Online adgang:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1243277/full
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