TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients

IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase of post-translational modifications in TDP-43, such...

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Prif Awduron:	Loreto Martinez-Gonzalez, Eva P. Cuevas, Carlota Tosat-Bitrián, Vanesa Nozal, Carmen Gil, Valle Palomo, Ángeles Martín-Requero, Ana Martinez
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2023-08-01
Cyfres:	Frontiers in Molecular Neuroscience
Pynciau:	TDP-43 pathology Alzheimer’s disease CK1 inhibitor TTBK1 inhibitor drug discovery
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1243277/full
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