The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model

Abstract Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ + / - ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear, and effective treatments for...

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Hauptverfasser:	Jian Jiang, Dilong Wang, Youheng Jiang, Xiuyan Yang, Runfeng Sun, Jinlong Chang, Wenhui Zhu, Peijia Yao, Kun Song, Shuwen Chang, Hong Wang, Lei Zhou, Xue-Song Zhang, Huiliang Li, Ningning Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-03-01
Schriftenreihe:	Microbiome
Schlagworte:	Autism Social deficits Gut microbiota metabolite Indole-3-propionic acid Mapk3 GABA
Online-Zugang:	https://doi.org/10.1186/s40168-024-01755-7
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