Indole-3-propionic acid promotes hepatic stellate cells inactivation

Abstract Background & aims We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis. Now, we explored the transcriptome and DNA methylome associated with serum IPA levels in human liver from obes...

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Principais autores:	Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, Eija Pirinen, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Maija Vaittinen, Jussi Pihlajamäki
格式:	Artigo
语言:	Inglês
出版:	BMC 2025-03-01
丛编:	Journal of Translational Medicine
主题:	Indole-3-propionic acid Liver fibrosis Hepatic stellate cells Apoptosis Mitochondrial metabolism Epigenetics
在线阅读:	https://doi.org/10.1186/s12967-025-06266-z
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