Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality

Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamma (Fcγ) receptor-expressing immune cells. We previ...

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Autors principals:	Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2017-09-01
Col·lecció:	Antibodies
Matèries:	Fc engineering silent effector function IgG1 IgG2 IgG4 IgG sigma developability pharmacokinetics crystal structure
Accés en línia:	https://www.mdpi.com/2073-4468/6/3/12
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