Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality

Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamma (Fcγ) receptor-expressing immune cells. We previ...

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Библиографические подробности

Главные авторы:	Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2017-09-01
Серии:	Antibodies
Предметы:	Fc engineering silent effector function IgG1 IgG2 IgG4 IgG sigma developability pharmacokinetics crystal structure
Online-ссылка:	https://www.mdpi.com/2073-4468/6/3/12
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