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SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity

Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity, whereas its loss in tumor cells increases tumor aggressivity. Investigations into the tumor suppression mechanisms so far...

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Principais autores: Subburaj Ilangumaran, Yirui Gui, Akhil Shukla, Sheela Ramanathan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-02-01
coleção:Frontiers in Immunology
Assuntos:
SOCS1
tumor suppressor
growth control
antigen presentation
tumor immunogenicity
checkpoint inhibition
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362224/full
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