Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis

BackgroundDegradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor for the synthesis of glycosaminoglycans, plays a biological role in glycocalyx remodeling and improves endothelial ba...

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Bibliografische Detailangaben

Hauptverfasser:	Jiayun Ying, Caiyan Zhang, Yaodong Wang, Tingyan Liu, Zhenhao Yu, Kexin Wang, Weiming Chen, Yufeng Zhou, Guoping Lu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-08-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	sepsis sulodexide glycocalyx remodeling endothelium barrier function Syndecan-1
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172892/full
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