Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency

Abstract Background Epigenetic modifications, nucleosome occupancy, and three-dimensional chromatin architecture collectively create a multi-layered, highly interactive regulatory system for controlling genomic functionality. Dysregulation of epigenetic processes leads to a plethora of abnormalities...

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Main Authors: Vrinda Venu, Eric M. Small, Cullen Roth, Samantha H. Adikari, Anna Hendrika Cornelia Vlot, Kyle A. Sullivan, Chanaka Roshan Abeyratne, Daniel Jacobson, Shawn R. Starkenburg, Karissa Y. Sanbonmatsu, Christina R. Steadman
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-10-01
Series:Epigenetics & Chromatin
Assuntos:
Multiscale chromatin organization
Chromatin architecture
Chromatin accessibility
Transcriptional dynamics
Functional epigenomics
Histone acetylation
Acceso en liña:https://doi.org/10.1186/s13072-025-00631-4
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