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Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction

Double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a critical upstream mediator of the ribotoxic stress response (RSR) to the trichothecene deoxynivalenol (DON) and other translational inhibitors. Here, we employed HeLa cell lysates to: (1) characterize PKR’s interactions with the ribosom...

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Autori principali: Hui-Ren Zhou, Kaiyu He, Jeff Landgraf, Xiao Pan, James J. Pestka
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2014-12-01
Serie:Toxins
Soggetti:
PKR
ribotoxic stress
rRNA
deoxynivalenol
anisomycin
ricin
translational inhibitor
quantitiative Western analysis
RNA immunoprecipitation
Accesso online:http://www.mdpi.com/2072-6651/6/12/3406
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