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Structures of Eukaryotic Ribosomal Stalk Proteins and Its Complex with Trichosanthin, and Their Implications in Recruiting Ribosome-Inactivating Proteins to the Ribosomes

Ribosome-inactivating proteins (RIP) are RNA N-glycosidases that inactivate ribosomes by specifically depurinating a conserved adenine residue at the α-sarcin/ricin loop of 28S rRNA. Recent studies have pointed to the involvement of the C-terminal domain of the eukaryotic stalk proteins in facilitat...

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Principais autores: Andrew K. H. Choi, Eddie C. K. Wong, Ka-Ming Lee, Kam-Bo Wong
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2015-02-01
Serier:Toxins
Fag:
ribosome
trichosanthin
ricin
stalk
ribosome inactivating proteins
elongation factors
Online adgang:http://www.mdpi.com/2072-6651/7/3/638
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