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Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles

Nanoparticles (NPs) typically accumulate in lysosomes. However, their impact on lysosomal function, as well as autophagy, a lysosomal degradative pathway, is still not well known. We have previously reported in the 1321N1 cell line that amine-modified polystyrene (NH2-PS) NPs induce apoptosis throug...

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Principais autores: Fengjuan Wang, Anna Salvati, Patricia Boya
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2018-04-01
Serier:Open Biology
Fag:
cationic nanoparticles
lysosomal membrane permeabilization
autophagy
reactive oxygen species
nanotoxicity
Online adgang:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170271
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