A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI transcriptomic biomarker (DDI = DNA damage-inducin...

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Detalhes bibliográficos

Principais autores:	Julie K. Buick, Andrew Williams, Matthew J. Meier, Carol D. Swartz, Leslie Recio, Rémi Gagné, Stephen S. Ferguson, Bevin P. Engelward, Carole L. Yauk
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-08-01
coleção:	Frontiers in Public Health
Assuntos:	genetic toxicology TGx-DDI genomic biomarker TGx-28.65 genomic biomarker metabolic activation toxicogenomics human health risk assessment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fpubh.2021.694834/full
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