Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells

Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades. However, the results of standard genotoxicity tests are often difficult to interpret due to lack of mode of action information....

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Julie K. Buick, Andrea Rowan-Carroll, Rémi Gagné, Andrew Williams, Renxiang Chen, Heng-Hong Li, Albert J. Fornace, Christy Chao, Bevin P. Engelward, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril D. Pettit, Jiri Aubrecht, Carole L. Yauk
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-09-01
Schriftenreihe:	Frontiers in Toxicology
Schlagworte:	genetic toxicology TGx-28.65 genomic biomarker toxicogenomics nitrofurantoin metronidazole novobiocin
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/ftox.2022.991590/full
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