Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader
Abstract Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that co...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Nature Portfolio
2024-04-01
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| Schriftenreihe: | Communications Chemistry |
| Online-Zugang: | https://doi.org/10.1038/s42004-024-01177-4 |
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