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Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

Abstract Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that co...

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Principais autores: Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2024-04-01
סדרה:Communications Chemistry
גישה מקוונת:https://doi.org/10.1038/s42004-024-01177-4
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