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Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin

Abstract Background Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for cancer cachexia therapy. However, sex‐sp...

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Principais autores: Xiaoling Zhong, Ashok Narasimhan, Libbie M. Silverman, Andrew R. Young, Safi Shahda, Sheng Liu, Jun Wan, Yunlong Liu, Leonidas G. Koniaris, Teresa A. Zimmers
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-08-01
Serier:Journal of Cachexia, Sarcopenia and Muscle
Fag:
Pancreatic cancer
Cachexia
Muscle wasting
Weight loss
Activin
ACVR2B
Online adgang:https://doi.org/10.1002/jcsm.12998
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