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Downregulation of Organ‐Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice

ABSTRACT Background Cancer cachexia is a multifactorial wasting syndrome marked by profound skeletal muscle loss. Tumours can release high levels of Activin A (ActA), which activates the ubiquitin‐proteasome pathway (UPP) and drives muscle wasting. Systemic blockade of the ActA pathway is associated...

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Main Authors: Cui Wang, Lin Gao, Rui Xue, Jia Su, Honghui Li, Wei Yang, Yan Tang, Zhihang Su, Shasha Min, Changyong Tang, Yuqi Zhu, Bo Mu, John R. Speakman, Xina Xie, Zesong Li
Format: Artigo
Language:Inglês
Published: Wiley 2026-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Activin A
cancer cachexia
heart and kidney
intramuscular fat infiltration
muscle atrophy
Online Access:https://doi.org/10.1002/jcsm.70237
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