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Metformin Treatment Shows Beneficial Effects on RTT-Associated Phenotypical Deficits in <i>Mecp2</i> T158M Male Mice

<b>Background</b>: Rett Syndrome (RTT) is a progressive neurodevelopmental disorder caused by <i>MECP2</i> gene mutations. MeCP2 protein binding to methylated DNA is involved in normal brain development and function. T158M is a common RTT-associated mutation, where a threonine is replaced with a met...

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Principais autores: Khatereh Saei Arezoumand, Ghanan Bin Akhtar, Ashraf Kadar Shahib, Jessica S. Jarmasz, Chris-Tiann Roberts, Abbas Rezaeian Mehrabadi, Carl O. Olson, Mojgan Rastegar
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Pharmaceuticals
Fag:
Rett Syndrome
MeCP2
T158M mutation
metformin
anxiety
locomotion
Online adgang:https://www.mdpi.com/1424-8247/19/4/621
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