Sex differences in the therapeutic effect of unaltered versus NFκB sensing IL-4 over-expressing mesenchymal stromal cells in a murine model of chronic inflammatory bone loss

Wear particles from joint arthroplasties induce chronic inflammation associated with prolonged upregulation of nuclear factor kappa-B (NF-κB) signaling in macrophages and osteoclasts, which leads to osteolysis and implant loosening. Mesenchymal stromal cell (MSC)-based therapy showed great potential...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Huaishuang Shen, Junichi Kushioka, Masakazu Toya, Takeshi Utsunomiya, Hirohito Hirata, Ejun Elijah Huang, Masanori Tsubosaka, Qi Gao, Xueping Li, Victoria Teissier, Ning Zhang, Stuart B. Goodman
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2022-08-01
سلاسل:	Frontiers in Bioengineering and Biotechnology
الموضوعات:	sex differences chronic inflammatory bone loss wear particles mesenchymal stromal cell macrophage
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.962114/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!