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Sex differences in the therapeutic effect of unaltered versus NFκB sensing IL-4 over-expressing mesenchymal stromal cells in a murine model of chronic inflammatory bone loss

Wear particles from joint arthroplasties induce chronic inflammation associated with prolonged upregulation of nuclear factor kappa-B (NF-κB) signaling in macrophages and osteoclasts, which leads to osteolysis and implant loosening. Mesenchymal stromal cell (MSC)-based therapy showed great potential...

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Hlavní autoři: Huaishuang Shen, Junichi Kushioka, Masakazu Toya, Takeshi Utsunomiya, Hirohito Hirata, Ejun Elijah Huang, Masanori Tsubosaka, Qi Gao, Xueping Li, Victoria Teissier, Ning Zhang, Stuart B. Goodman
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-08-01
Edice:Frontiers in Bioengineering and Biotechnology
Témata:
sex differences
chronic inflammatory bone loss
wear particles
mesenchymal stromal cell
macrophage
On-line přístup:https://www.frontiersin.org/articles/10.3389/fbioe.2022.962114/full
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