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N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifies signaling, while B-cell contraction following s...

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Principais autores: Anshuman Bhanja, Margaret K Seeley-Fallen, Michelle Lazzaro, Arpita Upadhyaya, Wenxia Song
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-12-01
Serier:eLife
Fag:
actin cytoskeleton
signal transduction
lymphocytes
B-cell receptor
N-WASP
Arp2/3
Online adgang:https://elifesciences.org/articles/87833
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