N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifies signaling, while B-cell contraction following s...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Anshuman Bhanja, Margaret K Seeley-Fallen, Michelle Lazzaro, Arpita Upadhyaya, Wenxia Song
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2023-12-01
Schriftenreihe:	eLife
Schlagworte:	actin cytoskeleton signal transduction lymphocytes B-cell receptor N-WASP Arp2/3
Online-Zugang:	https://elifesciences.org/articles/87833
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