Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction

An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N-acetylglucosamine in E. coli and N-acetylneuram...

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Podrobná bibliografie

Hlavní autoři:	Rongzhen Tian, Yanfeng Liu, Yanting Cao, Zhongjie Zhang, Jianghua Li, Long Liu, Guocheng Du, Jian Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2020-10-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-020-18960-1
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