Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

BackgroundThe mitochondrial pyruvate dehydrogenase complex (PDC) link glycolysis to the tricarboxylic acid cycle by decarboxylating pyruvate to acetyl coenzyme A irreversibly. Cancer cells are characterized by a shift in cellular metabolism from mitochondrial respiration to glycolysis. PDC activity...

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Autori principali:	Yu-Hsuan Kuo, Ti-Chun Chan, Hong-Yue Lai, Tzu-Ju Chen, Li-Ching Wu, Chung-Hsi Hsing, Chien-Feng Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2021-09-01
Serie:	Frontiers in Oncology
Soggetti:	pyruvate dehydrogenase kinase-3 urothelial carcinoma of the bladder urothelial carcinoma of upper urinary tract cancer metabolism metabolic reprogramming
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2021.749142/full
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